Effusion cytology of hepatocellular carcinoma with in situ hybridisation for human albumin

Stephen, M.R., Oien, K. , Ferrier, R.K. and Burnett, R.A. (1997) Effusion cytology of hepatocellular carcinoma with in situ hybridisation for human albumin. Journal of Clinical Pathology, 50(5), pp. 442-4. (PMID:9215133) (PMCID:PMC499952)

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Publisher's URL: http://jcp.bmj.com/content/50/5/442.long

Abstract

While the cytological features of hepatocellular carcinoma on fine needle aspiration cytology are well described, cases of hepatocellular carcinoma with malignant cells in ascitic fluid and their characteristics are not. A patient is described with cirrhosis resulting from chronic hepatitis B virus infection, ascites, and hepatocellular carcinoma diagnosed by effusion cytology. The malignant cells in the effusion were shown to be positive for alpha fetoprotein using immunocytochemistry, and for human albumin using in situ hybridisation, confirming the diagnosis of hepatocellular carcinoma. Further investigations in a terminally ill patient were thus avoided.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ferrier, Mr Roderick and Oien, Professor Karin
Authors: Stephen, M.R., Oien, K., Ferrier, R.K., and Burnett, R.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Clinical Pathology
Publisher:BMJ Publishing Group Ltd.
ISSN:0021-9746
ISSN (Online):1472-4146

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