Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori

El–Omar, E. M., Oien, K. , Murray, L. S., El–Nujumi, A., Wirz, A., Gillen, D., Williams, C., Fullarton, G. and McColl, K. E.L. (2000) Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori. Gastroenterology, 118(1), pp. 22-30. (doi:10.1016/S0016-5085(00)70410-0) (PMID:10611150)

El–Omar, E. M., Oien, K. , Murray, L. S., El–Nujumi, A., Wirz, A., Gillen, D., Williams, C., Fullarton, G. and McColl, K. E.L. (2000) Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori. Gastroenterology, 118(1), pp. 22-30. (doi:10.1016/S0016-5085(00)70410-0) (PMID:10611150)

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Abstract

Background & Aims:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer. The aim of this study was to determine the prevalence of atrophy and hypochlorhydria and their association with H. pylori infection in first-degree relatives of patients with gastric cancer. Methods:H. pylori status, gastric secretory function, and gastric histology were studied in 100 first-degree relatives of patients with noncardia gastric cancer and compared with those of controls with no family history of this cancer. Results: Compared with healthy controls, relatives of patients with gastric cancer had a higher prevalence of hypochlorhydria (27% vs. 3%) but a similar prevalence of H. pylori infection (63% vs. 64%). Relatives of cancer patients also had a higher prevalence of atrophy (34%) than patients with nonulcer dyspepsia (5%) matched for H. pylori prevalence. Among the relatives of cancer patients, the prevalence of atrophy and hypochlorhydria was increased only in those with evidence of H. pylori infection, was greater in relatives of patients with familial cancer than in relatives of sporadic cancer index patients, and increased with age. Eradication of H. pylori infection produced resolution of the gastric inflammation in each subject and resolution of hypochlorhydria and atrophy in 50% of the subjects. Conclusions: Relatives of patients with gastric cancer have an increased prevalence of precancerous gastric abnormalities, but this increase is confined to those with H. pylori infection. Consequently, prophylactic eradication of the infection should be offered to such subjects.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McColl, Professor Kenneth and Fullarton, Mr Grant and Oien, Dr Karin and Murray, Dr Lilian and Williams, Dr Craig
Authors: El–Omar, E. M., Oien, K., Murray, L. S., El–Nujumi, A., Wirz, A., Gillen, D., Williams, C., Fullarton, G., and McColl, K. E.L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Gastroenterology
Publisher:W.B. Saunders Co.
ISSN:0016-5085
ISSN (Online):1528-0012
Copyright Holders:Copyright © 2000 American Gastroenterological Association
First Published:First published in Gastroenterology 118(1):22-30
Publisher Policy:Reproduced in accordance with the publisher policy

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