Glycolipids from sponges. IV. Immunomodulating glycosyl ceramides from the marine sponge agelas dispar

Costantino, V., Fattorusso, E., Mangoni, A., Rosa, M. D., Ianaro, A. and Maffia, P. (1996) Glycolipids from sponges. IV. Immunomodulating glycosyl ceramides from the marine sponge agelas dispar. Tetrahedron, 52(5), pp. 1573-1578. (doi:10.1016/0040-4020(95)00986-8)

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Abstract

The GSL composition of the marine sponge Agelas dispar was investigated. In addition to four GSLs previously isolated from Agelas clathrodes (2 and 4), Agelas conifera (3), and Agelas longissima (5), the novel triglycosylceramide 1a was isolated as a major component of the GSL mixture. All the isolated GSLs were tested using the MLR assay, and only some of them were shown to be immunoactivating agents, suggesting a possible structure-activity relationship.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maffia, Dr Pasquale
Authors: Costantino, V., Fattorusso, E., Mangoni, A., Rosa, M. D., Ianaro, A., and Maffia, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Tetrahedron
Publisher:Elsevier B.V.
ISSN:0040-4020
ISSN (Online):1464-5416|

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