2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-κB

Ianaro, A., Maffia, P. , Cuzzocrea, S., Mazzon, E., Santoro, M. G., Di Rosa, M. and Ialenti, A. (2003) 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-κB. FEBS Letters, 553(1-2), pp. 21-27. (doi:10.1016/S0014-5793(03)00873-1) (PMID:14550540)

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Abstract

The aim of this study was to evaluate, using a rat model of balloon angioplasty, whether prostaglandin (PG) J2 and 2-cyclopenten-1-one are able to reduce restenosis. We found that both PGJ2 and 2-cyclopenten-1-one, administered by local application on carotid arteries, caused a dose-dependent inhibition of neointimal formation. Furthermore, both agents prevented vascular negative remodeling. The effect of these compounds on restenosis was correlated with an inhibition of nuclear factor-κB (NF-κB) activation as well as of intercellular adhesion molecule-1 (ICAM-1) protein expression in injured carotid arteries of control animals. Our results show that cyclopentenone PGs and their derivatives reduce restenosis and may have therapeutic relevance for the prevention of human restenosis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maffia, Dr Pasquale
Authors: Ianaro, A., Maffia, P., Cuzzocrea, S., Mazzon, E., Santoro, M. G., Di Rosa, M., and Ialenti, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:FEBS Letters
Publisher:Elsevier BV
ISSN:0014-5793
ISSN (Online):1873-3468

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