Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling

Carmody, R. J. and Chen, Y. H. (2007) Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling. Cellular and Molecular Immunology, 4(1), pp. 31-41.

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Toll-like receptors (TLRs) recognize distinct microbial components to initiate the innate and adaptive immune responses. TLR activation culminates in the expression of appropriate pro-inflammatory and immunomodulatory factors to meet pathogenic challenges. The transcription factor NF-kappaB is the master regulator of all TLR-induced responses and its activation is the pivotal event in TLR-mediated activation of the innate immune response. Many of the key molecular events required for TLR-induced NF-kappaB activation have been elucidated. However, much remains to be learned about the ability of TLRs to generate pathogen-specific responses using a limited number of transcription factors. This review will focus on our current understanding of NF-kappaB activation by TLRs and potential mechanisms for achieving a signal-specific response through NF-kappaB.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Carmody, Dr Ruaidhri
Authors: Carmody, R. J., and Chen, Y. H.
Subjects:Q Science > Q Science (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cellular and Molecular Immunology
Publisher:Nature Publishing Group
ISSN (Online):2042-0226

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