Derivation and validation of a novel prognostic scale (modified–stroke subtype, Oxfordshire community stroke project classification, age, and prestroke modified rankin) to predict early mortality in acute stroke

Abdul-Rahim, A. H. , Quinn, T. J. , Alder, S., Clark, A. B., Musgrave, S., Langhorne, P. , Potter, J. F. and Myint, P. K. (2016) Derivation and validation of a novel prognostic scale (modified–stroke subtype, Oxfordshire community stroke project classification, age, and prestroke modified rankin) to predict early mortality in acute stroke. Stroke, 47(1), pp. 74-79. (doi: 10.1161/strokeaha.115.009898) (PMID:26578661)

Abstract

Background and Purpose —The stroke subtype, Oxfordshire Community Stroke Project classification, age, and prestroke modified Rankin (SOAR) score is a prognostic scale proposed for early mortality prediction after acute stroke. We aimed to evaluate whether including a measure of initial stroke severity (National Institutes of Health Stroke Scale and modified-SOAR [mSOAR] scores) would improve the prognostic accuracy. Methods —Using Anglia Stroke and Heart Clinical Network data, 2008 to 2011, we assessed the performance of SOAR and mSOAR against in-hospital mortality using area under the receiver operating curve statistics. We externally validated the prognostic utility of SOAR and mSOAR using an independent cohort data set from Glasgow. We described calibration using Hosmer–Lemeshow goodness-of-fit test. Results —A total of 1002 patients were included in the derivation cohort, and 105 (10.5%) died as inpatients. The area under the receiver operating curves for outcome of early mortality derived from the SOAR and mSOAR scores were 0.79 (95% confidence interval, 0.75–0.84) and 0.83 (95% confidence interval, 0.79–0.86), respectively (P=0.001). The external validation data set contained 1012 patients with stroke; of which, 121 (12.0%) patients died within 90 days. The mSOAR scores identified the risk of early mortality ranging from 3% to 42%. External validation of mSOAR score yielded an area under the receiver operating curve of 0.84 (95% confidence interval, 0.82–0.88) for outcome of early mortality. Calibration was good (P=0.70 for the Hosmer–Lemeshow test). Conclusions —Adding National Institutes of Health Stroke Scale data to create a modified-SOAR score improved prognostic utility in both derivation and validation data sets. The mSOAR may have clinical utility by using easily available data to predict mortality.

• Item Type: Articles
• Additional Information: Dr Quinn was supported by a Chief Scientist’s Office/Stroke Association Senior Clinical Lecturer award.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Abdul-Rahim, Dr Azmil and Quinn, Professor Terry and Langhorne, Professor Peter
• Authors: Abdul-Rahim, A. H., Quinn, T. J., Alder, S., Clark, A. B., Musgrave, S., Langhorne, P., Potter, J. F., and Myint, P. K.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Stroke
• Publisher: American Heart Association
• ISSN: 0039-2499
• ISSN (Online): 1524-4628
• Copyright Holders: Copyright © 2015 American Heart Association
• First Published: First published in Stroke 47:74-79
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.