Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut

Naszai, M. , Carroll, L. and Cordero, J. (2015) Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut. Insect Biochemistry and Molecular Biology, 67, pp. 9-14. (doi: 10.1016/j.ibmb.2015.05.016) (PMID:26024801)

[img]
Preview
Text
114863.pdf - Accepted Version

2MB

Abstract

Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches. The intestinal epithelium has a remarkable regenerative capacity, which has made it a prime paradigm for the study of stem cell-driven tissue self-renewal. The discovery of the presence of stem cells in the adult midgut of the fruit fly Drosophila melanogaster has significantly impacted our understanding of the role of stem cells in intestinal homeostasis. Here we will review the current knowledge of the main mechanisms involved in the regulation of tissue homeostasis in the adult Drosophila midgut, with a focus on the role of stem cells in this process. We will also discuss processes involving acute or chronic disruption of normal intestinal homeostasis such as damage-induced regeneration and ageing.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cordero, Dr Julia and Naszai, Mr Mate
Authors: Naszai, M., Carroll, L., and Cordero, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Insect Biochemistry and Molecular Biology
Publisher:Elsevier Ltd.
ISSN:0965-1748
ISSN (Online):1879-0240
Copyright Holders:Copyright © 2015 Elsevier Ltd.
First Published:First published in Insect Biochemistry and Molecular Biology 67:9-14
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record