On the role of specific drug binding in modelling arterial eluting stents

Mcginty, S. and Pontrelli, G. (2016) On the role of specific drug binding in modelling arterial eluting stents. Journal of Mathematical Chemistry, 54(4), pp. 967-976. (doi:10.1007/s10910-016-0618-7)

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Abstract

In this paper we consider drug binding in the arterial wall following delivery by a drug-eluting stent. Whilst it is now generally accepted that a non-linear saturable reversible binding model is required to properly describe the binding process, the precise form of the binding model varies between authors. Our particular interest in this manuscript is in assessing to what extent modelling specific and non-specific binding in the arterial wall as separate phases is important. We study this issue by extending a recently developed coupled model of drug release and arterial tissue distribution, and comparing simulated profiles of drug concentration and drug mass in each phase within the arterial tissue.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mcginty, Dr Sean
Authors: Mcginty, S., and Pontrelli, G.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Journal of Mathematical Chemistry
Publisher:Springer
ISSN:0259-9791
ISSN (Online):1572-8897

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
579501Optimal Design of Drug Eluting StentsSimon KennedyEngineering & Physical Sciences Research Council (EPSRC)EP/J007579/1RI CARDIOVASCULAR & MEDICAL SCIENCES