Cognitive impairment among children at-risk for schizophrenia

Dickson, H., Cullen, A. E., Reichenberg, A., Hodgins, S., Campbell, D. D. , Morris, R. G. and Laurens, K. R. (2014) Cognitive impairment among children at-risk for schizophrenia. Journal of Psychiatric Research, 50, pp. 92-99. (doi: 10.1016/j.jpsychires.2013.12.003) (PMID:24373930)

Abstract

Adults with schizophrenia present cognitive impairments, as do individuals at ultra-high risk for the disorder, youth with relatives with schizophrenia spectrum disorders, and children with antecedents of schizophrenia. The present study aimed to determine if impairments in childhood differed depending on the definition of risk and/or on the degree of relatedness to an affected individual, and if impairments were explained by IQ. Four groups of children aged 9–12 years were studied: (1) 13 children with ≥1 first-degree or ≥2 second-degree affected relatives (high familial loading: FHxH); (2) 14 with ≥1 affected second-degree relative (lower familial loading: FHxL); (3) 32 with well-replicated antecedents of schizophrenia (ASz); and (4) 45 typically-developing (TD) children with neither a positive family history nor antecedents. Compared to TD children, both FHxH and ASz children exhibited significantly poorer verbal comprehension, scholastic achievement, and verbal working memory, while FHxH children additionally displayed significantly lower full-scale IQ, and verbal memory and executive function impairments. After adjusting statistical analyses for IQ, group differences were attenuated. Relative to TD children, FHxL children showed no significant differences in performance. The results imply that impairments in verbal comprehension, scholastic achievement, and verbal working memory may index vulnerability for schizophrenia among children with affected relatives with the disorder and among those with multiple antecedents of the disorder who have no affected relatives. More accurate identification of children at-risk for schizophrenia and the specific deficits that they present provides opportunities for interventions such as cognitive remediation that may impact the development of the illness.

• Item Type: Articles
• Additional Information: This work was supported by funding to KRL from a National Institute for Health Research (NIHR) Career Development Fellowship (CDF/08/01/015); a Bial Foundation Research Grant (36/06); a NARSAD Young Investigator Award (2005); and the British Medical Association Margaret Temple Award for schizophrenia research (2006). HD was supported by a PhD studentship from the NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King’s College London, United Kingdom.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Campbell, Dr Desmond
• Authors: Dickson, H., Cullen, A. E., Reichenberg, A., Hodgins, S., Campbell, D. D., Morris, R. G., and Laurens, K. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Journal of Psychiatric Research
• Publisher: Elsevier
• ISSN: 0022-3956
• ISSN (Online): 1879-1379
• Published Online: 18 December 2013