Diagnostic value of neutrophil-lymphocyte and albumin-globulin ratios in canine soft tissue sarcoma

Macfarlane, L., Morris, J. , Pratschke, K., Mellor, D. , Scase, T., McFarlane, M. and McLauchlan, G. (2016) Diagnostic value of neutrophil-lymphocyte and albumin-globulin ratios in canine soft tissue sarcoma. Journal of Small Animal Practice, 57(3), pp. 135-441. (doi:10.1111/jsap.12435) (PMID:26712718)

Macfarlane, L., Morris, J. , Pratschke, K., Mellor, D. , Scase, T., McFarlane, M. and McLauchlan, G. (2016) Diagnostic value of neutrophil-lymphocyte and albumin-globulin ratios in canine soft tissue sarcoma. Journal of Small Animal Practice, 57(3), pp. 135-441. (doi:10.1111/jsap.12435) (PMID:26712718)

Full text not currently available from Enlighten.

Abstract

OBJECTIVE: To investigate the ability of neutrophil-to-lymphocyte ratio and albumin-to-globulin ratio to differentiate soft tissue sarcoma from benign soft tissue tumours. METHODS: A retrospective study of pretreatment haematology and biochemistry in dogs diagnosed with soft tissue sarcoma or benign soft tissue tumours. The neutrophil-to-lymphocyte ratio and albumin-to- globulin ratio were compared between the two groups. In dogs diagnosed with soft tissue sarcoma, the relationship of neutrophil-to-lymphocyte ratio and albumin-to-globulin ratio to histological tumour grade (I to III) was assessed. RESULTS: In the dogs with soft tissue sarcoma (n=22), the neutrophil-to-lymphocyte ratio was significantly increased and the albumin-to-globulin ratio decreased compared to those with benign soft tissue tumours (n=14). The neutrophil-to-lymphocyte ratio and albumin-to globulin ratio were not useful as predictors of tumour grade in dogs diagnosed with soft tissue sarcoma. CLINICAL SIGNIFICANCE: Pretreatment neutrophil-to-lymphocyte ratio and albumin-to globulin ratio may aid with diagnosis and optimal treatment planning. Further investigation into their prognostic implications is warranted.

Item Type:Articles (Other)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McLauchlan, Mr Gerard and Pratschke, Ms Kathryn and Scase, Dr Timothy and Morris, Professor Joanna and Mellor, Professor Dominic
Authors: Macfarlane, L., Morris, J., Pratschke, K., Mellor, D., Scase, T., McFarlane, M., and McLauchlan, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of Small Animal Practice
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0022-4510
ISSN (Online):1748-5827
Published Online:29 December 2015

University Staff: Request a correction | Enlighten Editors: Update this record