Making sense of statistics in clinical trial reports: Part 1 of a 4-part series on statistics for clinical trials

Pocock, S. J., McMurray, J. J.V. and Collier, T. J. (2015) Making sense of statistics in clinical trial reports: Part 1 of a 4-part series on statistics for clinical trials. Journal of the American College of Cardiology, 66(22), pp. 2536-2549. (doi:10.1016/j.jacc.2015.10.014) (PMID:26653629)

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Abstract

This paper is a practical guide to the essentials of statistical analysis and reporting of randomized clinical trials (RCTs). It is the first in a series of 4 educational papers on statistical issues for RCTs, which will also include statistical controversies in RCT reporting and interpretation, the fundamentals of design for RCTs, and statistical challenges in the design and monitoring of RCTs. Here, we concentrate on displaying results in tables and figures, estimating treatment effects, expressing uncertainty using confidence intervals, and using p values wisely to assess the strength of evidence for a treatment difference. The various methods and their interpretation are illustrated by recent, topical cardiology trial results.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMurray, Professor John
Authors: Pocock, S. J., McMurray, J. J.V., and Collier, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of the American College of Cardiology
Publisher:Elsevier
ISSN:07351097
ISSN (Online):1558-3597

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