The host immune response to gastrointestinal nematode infection in sheep

McRae, K. M., Stear, M. J., Good, B. and Keane, O. M. (2015) The host immune response to gastrointestinal nematode infection in sheep. Parasite Immunology, 37(12), pp. 605-613. (doi: 10.1111/pim.12290) (PMID:26480845) (PMCID:PMC4744952)

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Abstract

Gastrointestinal nematode infection represents a major threat to the health, welfare and productivity of sheep populations worldwide. Infected lambs have a reduced ability to absorb nutrients from the gastrointestinal tract, resulting in morbidity and occasional mortality. The current chemo-dominant approach to nematode control is considered unsustainable due to the increasing incidence of anthelmintic resistance. In addition, there is growing consumer demand for food products from animals not subjected to chemical treatment. Future mechanisms of nematode control must rely on alternative, sustainable strategies such as vaccination or selective breeding of resistant animals. Such strategies take advantage of the host's natural immune response to nematodes. The ability to resist gastrointestinal nematode infection is considered to be dependent on the development of a protective acquired immune response, although the precise immune mechanisms involved in initiating this process remain to be fully elucidated. In this study, current knowledge on the innate and acquired host immune response to gastrointestinal nematode infection in sheep and the development of immunity is reviewed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stear, Professor Michael
Authors: McRae, K. M., Stear, M. J., Good, B., and Keane, O. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Parasite Immunology
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0141-9838
ISSN (Online):1365-3024
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Parasite Immunology 37(12):605-613
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
629831The influence of selective breeding on MHC diversityMichael StearBiotechnology and Biological Sciences Research Council (BBSRC)BB/L004070/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED