Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Morrison, D. J. and Preston, T. (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes, 7(3), pp. 189-200. (doi: 10.1080/19490976.2015.1134082) (PMID:26963409)

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The formation of SCFA is the result of a complex interplay between diet and the gut microbiota within the gut lumen environment. The discovery of receptors, across a range of cell and tissue types for which short chain fatty acids SCFA appear to be the natural ligands, has led to increased interest in SCFA as signaling molecules between the gut microbiota and the host. SCFA represent the major carbon flux from the diet through the gut microbiota to the host and evidence is emerging for a regulatory role of SCFA in local, intermediary and peripheral metabolism. However, a lack of well-designed and controlled human studies has hampered our understanding of the significance of SCFA in human metabolic health. This review aims to pull together recent findings on the role of SCFA in human metabolism to highlight the multi-faceted role of SCFA on different metabolic systems.

Item Type:Articles
Additional Information:Funding for this article provided by BBSRC grants BB/L004259/1 to Imperial College, and BB/H004815/1, BB/H532091/1, and BB/L025418/1 to Scottish Unversities Environmental Research Centre.
Glasgow Author(s) Enlighten ID:Preston, Professor Tom and Morrison, Dr Douglas
Authors: Morrison, D. J., and Preston, T.
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:Gut Microbes
Publisher:Taylor and Francis
ISSN (Online):1949-0984
Published Online:10 March 2016
Copyright Holders:Copyright © 2016 Douglas J. Morrison and Tom Preston
First Published:First published in Gut Microbes 7(3): 189-200
Publisher Policy:Reproduced under a Creative Commons License

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