The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD

Watt, J., Kennedy, S., Ahmed, N., Hayhurst, J., McClure, J. D. , Berry, C. , Wadsworth, R. M. and Oldroyd, K. G. (2016) The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD. Open Heart, 3(1), e000342. (doi:10.1136/openhrt-2015-000342) (PMID:26848395) (PMCID:PMC4731840)

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Abstract

Objective The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). Methods 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34+/KDR+ cells. Results Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. Conclusions Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis.

Item Type:Articles
Additional Information:This work was supported by a British Heart Foundation (BHF) Junior Research Fellowship (FS/05/096/19933) awarded to Dr J Watt.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Oldroyd, Dr Keith and Berry, Professor Colin and McClure, Dr John and Kennedy, Dr Simon
Authors: Watt, J., Kennedy, S., Ahmed, N., Hayhurst, J., McClure, J. D., Berry, C., Wadsworth, R. M., and Oldroyd, K. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Open Heart
Publisher:BMJ
ISSN:2053-3624
ISSN (Online):2053-3624
Copyright Holders:Copyright © 2016 Watt J, Kennedy S, Ahmed N, et al.
First Published:First published in Open Heart 3(1):e000342
Publisher Policy:Reproduced under a Creative Commons License
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