Association between landscape factors and spatial patterns of plasmodium knowlesi Infections in Sabah, Malaysia

Fornace, K.M. , Abidin, T.R., Alexander, N., Brock, P. , Grigg, M.J., William, T., Menon, J., Drakeley, C.J. and Cox, J. (2016) Association between landscape factors and spatial patterns of plasmodium knowlesi Infections in Sabah, Malaysia. Emerging Infectious Diseases, 22(2), pp. 201-208. (doi: 10.3201/eid2202.150656) (PMID:26812373) (PMCID:PMC4734530)

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Abstract

The zoonotic malaria species Plasmodium knowlesi has become the main cause of human malaria in Malaysian Borneo. Deforestation and associated environmental and population changes have been hypothesized as main drivers of this apparent emergence. We gathered village-level data for P. knowlesi incidence for the districts of Kudat and Kota Marudu in Sabah state, Malaysia, for 2008–2012. We adjusted malaria records from routine reporting systems to reflect the diagnostic uncertainty of microscopy for P. knowlesi. We also developed negative binomial spatial autoregressive models to assess potential associations between P. knowlesi incidence and environmental variables derived from satellite-based remote-sensing data. Marked spatial heterogeneity in P. knowlesi incidence was observed, and village-level numbers of P. knowlesi cases were positively associated with forest cover and historical forest loss in surrounding areas. These results suggest the likelihood that deforestation and associated environmental changes are key drivers in P. knowlesi transmission in these areas.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Brock, Dr Patrick and Fornace, Dr Kimberly
Authors: Fornace, K.M., Abidin, T.R., Alexander, N., Brock, P., Grigg, M.J., William, T., Menon, J., Drakeley, C.J., and Cox, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Emerging Infectious Diseases
Publisher:U.S. Department of Health and Human Services
ISSN:1080-6040
ISSN (Online):1080-6059
Copyright Holders:Copyright © 2015 Centers for Disease Control and Prevention
First Published:First published in Emerging Infectious Diseases 22:2
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
538423Defining the biomedical, environmental and social risk factors for human infection with Plasmodium knowlesi (a.k.a. 'Monkeybar')Heather FergusonMedical Research Council (MRC)G1100796/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED