Jaagsiekte sheep retrovirus is not detected in human lung adenocarcinomas expressing antigens related to the Gag polyprotein of betaretrovirus

De Las Heras Guillamon, M., Murcia, P. , Ortín, A., Azúa, J., Borderías, L., Álvarez, R., Jiménez-Más, J. A., Marchetti, A. and Palmarini, M. (2007) Jaagsiekte sheep retrovirus is not detected in human lung adenocarcinomas expressing antigens related to the Gag polyprotein of betaretrovirus. Cancer Letters, 258(1), pp. 22-30. (doi:10.1016/j.canlet.2007.08.006) (PMID:17889995)

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Abstract

A proportion of human lung adenocarcinomas (hLACs) express an antigen related to the major capsid protein (CA) of Jaagsiekte sheep retrovirus (JSRV), a Betaretrovirus that causes a transmissible lung cancer in sheep. In this study, we have investigated whether JSRV or related betaretroviruses are expressed in hLACs. Results obtained indicate that JSRV is not associated with human lung adenocarcinomas. However, a proportion of hLACs reacted positively in immunohistochemistry with antibodies specific towards different domains of the JSRV Gag suggesting that a bona fide retrovirus antigen could be expressed in these tumours. Further studies will be necessary to ascertain whether the detection of antigens cross-reacting with betaretrovirus Gag antisera in some hLACs is due to expression of a human endogenous retrovirus or, more unlikely, of an uncharacterized exogenous retrovirus.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Palmarini, Professor Massimo and De Las Heras Guillamon, Prof Marcelo and Murcia, Dr Pablo
Authors: De Las Heras Guillamon, M., Murcia, P., Ortín, A., Azúa, J., Borderías, L., Álvarez, R., Jiménez-Más, J. A., Marchetti, A., and Palmarini, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cancer Letters
Publisher:Elsevier Ireland Ltd
ISSN:0304-3835
ISSN (Online):1872-7980

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