Alonso-Padilla, J., Papp, T., Kaján, G. L., Benkő, M., Havenga, M., Lemckert, A., Harrach, B. and Baker, A. H. (2016) Development of novel adenoviral vectors to overcome challenges observed with HAdV-5 based constructs. Molecular Therapy, (doi: 10.1038/mt.2015.194) (PMID:26478249) (PMCID:PMC4754553)
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Abstract
Recombinant vectors based on human adenovirus serotype 5 (HAdV-5) have been extensively studied in pre-clinical models and clinical trials over the last two decades. However, the thorough understanding of the HAdV-5 interaction with human subjects has uncovered major concerns about its product applicability. High vector-associated toxicity and widespread pre-existing immunity have been shown to significantly impede the effectiveness of HAdV-5 mediated gene transfer. It is therefore that the in depth knowledge attained working on HAdV-5 is currently being used to develop alternative vectors. Here, we provide a comprehensive overview of data obtained in recent years disqualifying the HAdV-5 vector for systemic gene delivery as well as novel strategies being pursued to overcome the limitations observed with particular emphasis on the ongoing vectorization efforts to obtain vectors based on alternative serotypes.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Baker, Professor Andrew |
| Authors: | Alonso-Padilla, J., Papp, T., Kaján, G. L., Benkő, M., Havenga, M., Lemckert, A., Harrach, B., and Baker, A. H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Molecular Therapy |
| Publisher: | Nature Publishing Group |
| ISSN: | 1525-0016 |
| ISSN (Online): | 1525-0024 |
| Copyright Holders: | Copyright © 2015 Nature Publishing Group |
| First Published: | First published in Molecular Therapy 2015 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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