Protein–protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches

Byron, O. and Vestergaard, B. (2015) Protein–protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches. Current Opinion in Structural Biology, 35, pp. 76-86. (doi:10.1016/j.sbi.2015.09.003)

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Abstract

Responsive formation of protein:protein interaction (PPI) upon diverse stimuli is a fundament of cellular function. As a consequence, PPIs are complex, adaptive entities, and exist in structurally heterogeneous interplays defined by the energetic states of the free and complexed protomers. The biophysical and structural investigations of PPIs consequently demand hybrid approaches, implementing orthogonal methods and strategies for global data analysis. Currently, impressive developments in hardware and software within several methodologies define a new era for the biostructural community. Data can be obtained at increasing resolution, at relevant time-scales and under increasingly relevant experimental conditions, intricate data are interpreted reliably, and the questions posed and answered grow in complexity. With this review, highlights from the study of PPIs using a multitude of biophysical methods, are reported. The aim is to depict how the elucidation of the interplay of structures requires the interplay of methods.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Byron, Professor Olwyn
Authors: Byron, O., and Vestergaard, B.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Current Opinion in Structural Biology
Publisher:Elsevier
ISSN:0959-440X
ISSN (Online):1879-033X

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