A field vaccine trial in Tanzania demonstrates partial protection against malignant catarrhal fever in cattle

Lankester, F. et al. (2016) A field vaccine trial in Tanzania demonstrates partial protection against malignant catarrhal fever in cattle. Vaccine, 34(6), pp. 831-838. (doi:10.1016/j.vaccine.2015.12.009) (PMID:26706270) (PMCID:PMC4742522)

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Abstract

Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease of cattle that, in East Africa, results from transmission of the causative virus, alcelaphine herpesvirus 1 (AlHV-1), from wildebeest. A vaccine field trial involving an attenuated AlHV-1 virus vaccine was performed over two wildebeest calving seasons on the Simanjiro Plain of northern Tanzania. Each of the two phases of the field trial consisted of groups of 50 vaccinated and unvaccinated cattle, which were subsequently exposed to AlHV-1 challenge by herding toward wildebeest. Vaccination resulted in the induction of virus-specific and virus-neutralizing antibodies. Some cattle in the unvaccinated groups also developed virus-specific antibody responses but only after the start of the challenge phase of the trial. PCR of DNA from blood samples detected AlHV-1 infection in both groups of cattle but the frequency of infection was significantly lower in the vaccinated groups. Some infected animals showed clinical signs suggestive of MCF but few animals went on to develop fatal MCF, with similar numbers in vaccinated and unvaccinated groups. This study demonstrated a baseline level of MCF-seropositivity among cattle in northern Tanzania of 1% and showed that AlHV-1 virus-neutralizing antibodies could be induced in Tanzanian zebu shorthorn cross cattle by our attenuated vaccine, a correlate of protection in previous experimental trials. The vaccine reduced infection rates by 56% in cattle exposed to wildebeest but protection from fatal MCF could not be determined due to the low number of fatal cases.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Russell, Dr George and Cleaveland, Professor Sarah
Authors: Lankester, F., Russell, G.C., Lugelo, A., Ndabigayec, A., Mnyambwac, N., Keyyu, J., Kazwala, R., Grant, D., Percival, A., Deane, D., Haig, D.M., and Cleaveland, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Vaccine
Publisher:Elsevier
ISSN:0264-410X
ISSN (Online):1873-2518
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Vaccine 34(6):831-838
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
518911Development of a vaccination strategy for the control of malignant catarrhal feverSarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/H009035/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED