Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12

Komai-Koma, M., Wang, E., Kurowska-Stolarska, M. , Li, D., McSharry, C. and Xu, D. (2016) Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12. Immunobiology, 221(3), pp. 412-417. (doi:10.1016/j.imbio.2015.11.013) (PMID:26688508) (PMCID:PMC4731778)

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Abstract

No abstract available.The pro-Th2 cytokine IL-33 is now emerging as an important Th1 cytokine-IFN-γ inducer in murine CD4+ T cells that is essential for protective cell-mediated immunity against viral infection in mice. However, whether IL-33 can promote human Th1 cell differentiation and how IL-33 polarizes Th1 cells is less understood. We assessed the ability of IL-33 to induce Th1 cell differentiation and IFN-γ production in vitro and in vivo. We report here that IL-33 alone had no ability in Th1 cell polarization. However it potentiated IL-12-mediated Th1 cell differentiation and IFN-γ production in TCR-stimulated murine and human CD4+ T cells in vitro and in vivo. IL-33 promoted Th1 cell development via MyD88 and synergized with IL-12 to enhance St2 and IL-12R expression in CD4+ T cells. These data therefore provide a novel mechanism for Th1 cell differentiation and optimal induction of a Type 1 response. Thus, IL-33 is capable of inducing IL-12-dependent Th1 cell differentiation in human and mouse CD4+ T cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Xu, Dr Damo and Komai-Koma, Dr Mousa and Kurowska-Stolarska, Dr Mariola and McSharry, Dr Charles
Authors: Komai-Koma, M., Wang, E., Kurowska-Stolarska, M., Li, D., McSharry, C., and Xu, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Immunobiology
Publisher:Elsevier
ISSN:0171-2985
ISSN (Online):1878-327
Published Online:07 December 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Immunobiology 221(3):412-417
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
514991IL-33: a novel cytokine that integrates innate and adaptive immune activation in inflammatory arthritisDamo XuArthritis Research UK (ARC)18912III -IMMUNOLOGY