Palmer, T. P. and Yarwood, S. J. (2015) Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1. Journal of Cell Signaling, 1(1), 1000103. (doi: 10.4172/jcs.1000103)
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Publisher's URL: http://www.omicsonline.org/open-access/regulation-of-antiinflammatory-gene-expression-in-vascular-endothelialcells-by-epac1-jcs-1000103.php?aid=64605
Abstract
Suppressor of cytokine signalling 3 (SOCS3) is a potent inhibitor of pro-inflammatory pathways involved in atherogenesis and the development of neo-intimal hyperplasia (NIH), which contributes to the in-stent re-stenosis responsible for the failure of percutaneous coronary intervention (PCI) procedures. We have shown that cyclic AMP sensor EPAC1 triggers induction of the SOCS3 gene in vascular endothelial cells (VECs), thereby attenuating interleukin 6 (IL-6)-mediated pro-inflammatory signalling. We propose that EPAC1 localisation to the nuclear pore controls cyclic AMP-mediated activation of a C/EBPβ/c-Jun transcriptional complex, leading to SOCS3 induction and suppression of pro-inflammatory signalling. Future work in this area will involve an integrated approach to determine the wider significance of the EPAC1-C/EBPβ/c-Jun pathway in controlling human VEC function and identify new therapeutic targets for management of chronic inflammation in vascular settings.
| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Yarwood, Dr Stephen and Palmer, Dr Timothy |
| Authors: | Palmer, T. P., and Yarwood, S. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Journal of Cell Signaling |
| Publisher: | OMICS |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Journal of Cell Signaling 1(1):1000103 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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