Rethinking the old antiviral drug moroxydine: discovery of novel analogues as anti-hepatitis C virus (HCV) agents

Magri, A., Reilly, R., Scalacci, N., Radi, M., Hunter, M., Ripoll, M., Patel, A. and Castagnolo, D. (2015) Rethinking the old antiviral drug moroxydine: discovery of novel analogues as anti-hepatitis C virus (HCV) agents. Bioorganic and Medicinal Chemistry Letters, 25(22), pp. 5372-5376. (doi:10.1016/j.bmcl.2015.09.029) (PMID:26428870)

Full text not currently available from Enlighten.

Abstract

The discovery of a novel class of HCV inhibitors is described. The new amidinourea compounds were designed as isosteric analogues of the antiviral drug moroxydine. The two derivatives 11g and 11h showed excellent HCV inhibition activity and viability and proved to inhibit a step(s) of the RNA replication. The new compounds have been synthesized in only three synthetic steps from cheap building blocks and in high yields, thus turning to be promising drug candidates in the development of cheaper HCV treatments.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Patel, Professor Arvind and Magri, Mr Andrea
Authors: Magri, A., Reilly, R., Scalacci, N., Radi, M., Hunter, M., Ripoll, M., Patel, A., and Castagnolo, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Bioorganic and Medicinal Chemistry Letters
Publisher:Pergamon
ISSN:0960-894X
ISSN (Online):1464-3405

University Staff: Request a correction | Enlighten Editors: Update this record