Rethinking the old antiviral drug moroxydine: discovery of novel analogues as anti-hepatitis C virus (HCV) agents

Magri, A., Reilly, R., Scalacci, N., Radi, M., Hunter, M., Ripoll, M., Patel, A. and Castagnolo, D. (2015) Rethinking the old antiviral drug moroxydine: discovery of novel analogues as anti-hepatitis C virus (HCV) agents. Bioorganic and Medicinal Chemistry Letters, 25(22), pp. 5372-5376. (doi: 10.1016/j.bmcl.2015.09.029) (PMID:26428870)

Abstract

The discovery of a novel class of HCV inhibitors is described. The new amidinourea compounds were designed as isosteric analogues of the antiviral drug moroxydine. The two derivatives 11g and 11h showed excellent HCV inhibition activity and viability and proved to inhibit a step(s) of the RNA replication. The new compounds have been synthesized in only three synthetic steps from cheap building blocks and in high yields, thus turning to be promising drug candidates in the development of cheaper HCV treatments.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Patel, Professor Arvind and Magri, Mr Andrea
• Authors: Magri, A., Reilly, R., Scalacci, N., Radi, M., Hunter, M., Ripoll, M., Patel, A., and Castagnolo, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Bioorganic and Medicinal Chemistry Letters
• Publisher: Pergamon
• ISSN: 0960-894X
• ISSN (Online): 1464-3405