Wireless fluorescence capsule for endoscopy using single photon-based detection

Al-Rawhani, M. A., Beeley, J. and Cumming, D. R. S. (2015) Wireless fluorescence capsule for endoscopy using single photon-based detection. Scientific Reports, 5, 18591. (doi:10.1038/srep18591) (PMID:26678456) (PMCID:PMC4683524)

Al-Rawhani, M. A., Beeley, J. and Cumming, D. R. S. (2015) Wireless fluorescence capsule for endoscopy using single photon-based detection. Scientific Reports, 5, 18591. (doi:10.1038/srep18591) (PMID:26678456) (PMCID:PMC4683524)

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Abstract

Fluorescence Imaging (FI) is a powerful technique in biological science and clinical medicine. Current FI devices that are used either for in-vivo or in-vitro studies are expensive, bulky and consume substantial power, confining the technique to laboratories and hospital examination rooms. Here we present a miniaturised wireless fluorescence endoscope capsule with low power consumption that will pave the way for future FI systems and applications. With enhanced sensitivity compared to existing technology we have demonstrated that the capsule can be successfully used to image tissue autofluorescence and targeted fluorescence via fluorophore labelling of tissues. The capsule incorporates a state-of-the-art complementary metal oxide semiconductor single photon avalanche detector imaging array, miniaturised optical isolation, wireless technology and low power design. When in use the capsule consumes only 30.9 mW, and deploys very low-level 468 nm illumination. The device has the potential to replace highly power-hungry intrusive optical fibre based endoscopes and to extend the range of clinical examination below the duodenum. To demonstrate the performance of our capsule, we imaged fluorescence phantoms incorporating principal tissue fluorophores (flavins) and absorbers (haemoglobin). We also demonstrated the utility of marker identification by imaging a 20 μM fluorescein isothiocyanate (FITC) labelling solution on mammalian tissue.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Al-Rawhani, Dr Mohammed and Cumming, Professor David and Beeley, Mr James
Authors: Al-Rawhani, M. A., Beeley, J., and Cumming, D. R. S.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Scientific Report 5:18591
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
605821The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - ENGINEERING ELECTRONICS & NANO ENG
615381Sonopill: minimally invasive gastrointestinal diagnosis and therapyDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/K034537/1ENG - ENGINEERING ELECTRONICS & NANO ENG