Seroepidemiological study of interepidemic Rift Valley fever virus infection among persons with intense ruminant exposure in Madagascar and Kenya

Gray, G. C. et al. (2015) Seroepidemiological study of interepidemic Rift Valley fever virus infection among persons with intense ruminant exposure in Madagascar and Kenya. American Journal of Tropical Medicine and Hygiene, 93(6), pp. 1364-1370. (doi: 10.4269/ajtmh.15-0383) (PMID:26458775) (PMCID:PMC4674260)

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Abstract

In this cross-sectional seroepidemiological study we sought to examine the evidence for circulation of Rift Valley fever virus (RVFV) among herders in Madagascar and Kenya. From July 2010 to June 2012, we enrolled 459 herders and 98 controls (without ruminant exposures) and studied their sera (immunoglobulin G IgG and IgM through enzyme-linked immunosorbent assay ELISA and plaque reduction neutralization test PRNT assays) for evidence of previous RVFV infection. Overall, 59 (12.9%) of 459 herders and seven (7.1%) of the 98 controls were positive by the IgG ELISA assay. Of the 59 ELISA-positive herders, 23 (38.9%) were confirmed by the PRNT assay (21 from eastern Kenya). Two of the 21 PRNT-positive study subjects also had elevated IgM antibodies against RVFV suggesting recent infection. Multivariate modeling in this study revealed that being seminomadic (odds ratio OR = 6.4, 95% confidence interval CI = 2.1–15.4) was most strongly associated with antibodies against RVFV. Although we cannot know when these infections occurred, it seems likely that some interepidemic RVFV infections are occurring among herders. As there are disincentives regarding reporting RVFV outbreaks in livestock or wildlife, it may be prudent to conduct periodic, limited, active seroepidemiological surveillance for RVFV infections in herders, especially in eastern Kenya.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:De Glanville, Dr William
Authors: Gray, G. C., Anderson, B. D., LaBeaud, A. D., Heraud, J.-M., Fèvre, E. M., Andriamandimby, S. F., Cook, E. A. J., Dahir, S., De Glanville, W. A., Heil, G. L., Khan, S. U., Muiruri, S., Olive, M.-M., Thomas, L. F., Merrill, H. R., Merrill, M. L. M., and Richt, J. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:American Journal of Tropical Medicine and Hygiene
Publisher:American Society of Tropical Medicine and Hygiene
ISSN:0002-9637
ISSN (Online):0002-9637
Copyright Holders:Copyright © 2015 The American Society of Tropical Medicine and Hygiene
First Published:First published in American Journal of Tropical Medicine and Hygiene 93(6):1364-1370
Publisher Policy:Reproduced under a creative commons license

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