Geographical distribution of Trypanosoma cruzi genotypes in Venezuela

Carrasco, H.J. et al. (2012) Geographical distribution of Trypanosoma cruzi genotypes in Venezuela. PLoS Neglected Tropical Diseases, 6(6), e1707. (doi:10.1371/journal.pntd.0001707) (PMID:22745843) (PMCID:PMC3383755)

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Chagas disease is an endemic zoonosis native to the Americas and is caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The parasite is also highly genetically diverse, with six discrete typing units (DTUs) reported TcI – TcVI. These DTUs broadly correlate with several epidemiogical, ecological and pathological features of Chagas disease. In this manuscript we report the most comprehensive evaluation to date of the genetic diversity of T. cruzi in Venezuela. The dataset includes 778 samples collected and genotyped over the last twelve years from multiple hosts and vectors, including nine wild and domestic mammalian host species, and seven species of triatomine bug, as well as from human sources. Most isolates (732) can be assigned to the TcI clade (94.1%); 24 to the TcIV group (3.1%) and 22 to TcIII (2.8%). Importantly, among the 95 isolates genotyped from human disease cases, 79% belonged to TcI - a DTU common in the Americas, however, 21% belonged to TcIV- a little known genotype previously thought to be rare in humans. Furthermore, were able to assign multiple oral Chagas diseases cases to TcI in the area around the capital, Caracas. We discuss our findings in the context of T. cruzi DTU distributions elsewhere in the Americas, and evaluate the impact they have on the future of Chagas disease control in Venezuela.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Llewellyn, Dr Martin
Authors: Carrasco, H.J., Segovia, M., Llewellyn, M.S., Morocoima, A., Urdaneta-Morales, S., Martínez, C., Martínez, C.E., Garcia, C., Rodríguez, M., Espinosa, R., de Noya, B.A., Díaz-Bello, Z., Herrera, L., Fitzpatrick, S., Yeo, M., Miles, M.A., and Feliciangeli, M.D.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:PLoS Neglected Tropical Diseases
Publisher:Public Library of Science
ISSN (Online):1935-2735
Copyright Holders:Copyright © 2012 Carrasco et al.
First Published:First published in PLoS Neglected Tropical Diseases 6(6):e1707
Publisher Policy:Reproduced under a Creative Commons License

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