Salome, M. , Campos, J. and Keeshan, K. (2015) TRIB2 and the ubiquitin proteasome system in cancer. Biochemical Society Transactions, 43(5), pp. 1089-1094. (doi: 10.1042/bst20150103) (PMID:26517929)
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Abstract
Tribbles family of pseudokinase proteins are known to mediate the degradation of target proteins in Drosophila and mammalian systems. The main protein proteolysis pathway in eukaryotic cells is the ubiquitin proteasome system (UPS). The tribbles homolog 2 (TRIB2) mammalian family member has been well characterized for its role in murine and human leukaemia, lung and liver cancer. One of the most characterized substrates for TRIB2-mediated degradation is the myeloid transcription factor CCAAT enhancer binding protein α (C/EBPα). However, across a number of cancers, the molecular interactions that take place between TRIB2 and factors involved in the UPS are varied and have differential downstream effects. This review summarizes our current knowledge of these interactions and how this information is important for our understanding of TRIB2 in cancer.
| Item Type: | Articles |
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| Additional Information: | The final version of record is available at http://www.biochemsoctrans.org/content/43/5/1089 |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Keeshan, Dr Karen and Salome, Ms Mara and Campos, Ms Joana |
| Authors: | Salome, M., Campos, J., and Keeshan, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Biochemical Society Transactions |
| Publisher: | Portland Press Ltd. |
| ISSN: | 0300-5127 |
| ISSN (Online): | 1470-8752 |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Biochemical Society Transactions 43(5):4089-1094 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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