A 1D Mechanistic Model Can Predict Duration of In-Vivo Drug Release from Drug-Eluting Stents

McGinty, S. and Pontrelli, G. (2015) A 1D Mechanistic Model Can Predict Duration of In-Vivo Drug Release from Drug-Eluting Stents. In: 4th International Conference on Computational & Mathematical Biomedical Engineering, Paris, France, 29 June - 1 July 2015, pp. 658-661. ISBN 9780956291431

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Publisher's URL: http://www.compbiomed.net/2015/cmbe-proceedings.htm

Abstract

In this paper we consider a mechanistic 1D dissolution-diffusion model for drug release from a drugeluting stent coupled with absorption in the arterial wall. Within the drug coating layer of the stent, we propose a general model of diffusion-dissolution, which encompasses several existing approaches in the literature. Importantly, the drug dynamics depend on the coupling of drug release with tissue absorption, and so we additionally model the saturable drug binding within the tissue layer, supported by appropriate coupling conditions. We demonstrate that the coupled 1D model is capable of predicting important characteristics such as the correct duration of drug release reported in existing in-vivo studies.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mcginty, Dr Sean
Authors: McGinty, S., and Pontrelli, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Science and Engineering > School of Engineering > Biomedical Engineering
ISSN:2227-3085
ISBN:9780956291431

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