Customizable 3D printed 'Plug and Play' millifluidic devices for programmable fluidics

Tsuda, S., Jaffery, H., Doran, D., Hezwani, M., Robbins, P. J., Yoshida, M. and Cronin, L. (2015) Customizable 3D printed 'Plug and Play' millifluidic devices for programmable fluidics. PLoS ONE, 10(11), e0141640. (doi:10.1371/journal.pone.0141640) (PMID:26558389) (PMCID:PMC4641590)

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Abstract

Three dimensional (3D) printing is actively sought after in recent years as a promising novel technology to construct complex objects, which scope spans from nano- to over millimeter scale. Previously we utilized Fused deposition modeling (FDM)-based 3D printer to construct complex 3D chemical fluidic systems, and here we demonstrate the construction of 3D milli-fluidic structures for programmable liquid handling and control of biological samples. Basic fluidic operation devices, such as water-in-oil (W/O) droplet generators for producing compartmentalized mono-disperse droplets, sensor-integrated chamber for online monitoring of cellular growth, are presented. In addition, chemical surface treatment techniques are used to construct valve-based flow selector for liquid flow control and inter-connectable modular devices for networking fluidic parts. As such this work paves the way for complex operations, such as mixing, flow control, and monitoring of reaction / cell culture progress can be carried out by constructing both passive and active components in 3D printed structures, which designs can be shared online so that anyone with 3D printers can reproduce them by themselves.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Yoshida, Mari and Tsuda, Dr Soichiro and Cronin, Professor Lee
Authors: Tsuda, S., Jaffery, H., Doran, D., Hezwani, M., Robbins, P. J., Yoshida, M., and Cronin, L.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
ISSN (Online):1932-6203
Copyright Holders:Copyright © 2015 Tsuda et al.
First Published:First published in PLoS ONE 10(11):e0141640
Publisher Policy:Reproduced under a Creative Commons License

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