Modelling drug-eluting stents

McGinty, S. , McKee, S., Wadsworth, R. M. and McCormick, C. (2011) Modelling drug-eluting stents. Mathematical Medicine and Biology, 28(1), pp. 1-29. (doi:10.1093/imammb/dqq003)

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Abstract

In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mcginty, Dr Sean
Authors: McGinty, S., McKee, S., Wadsworth, R. M., and McCormick, C.
College/School:College of Science and Engineering > School of Engineering
Journal Name:Mathematical Medicine and Biology
Publisher:Oxford University Press
ISSN:1477-8599
ISSN (Online):1477-8602

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