Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice

Rodgers, J. , Bradley, B., Kennedy, P. G.E. and Sternberg, J. M. (2015) Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice. PLoS Neglected Tropical Diseases, 9(10), e0004201. (doi: 10.1371/journal.pntd.0004201) (PMID:26505761) (PMCID:PMC4624684)

Abstract

Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bradley, Mrs Barbara and Rodgers, Dr Jean and Kennedy, Professor Peter
• Authors: Rodgers, J., Bradley, B., Kennedy, P. G.E., and Sternberg, J. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: PLoS Neglected Tropical Diseases
• Publisher: Public Library of Science
• ISSN: 1935-2727
• ISSN (Online): 1935-2735
• Copyright Holders: Copyright © 2015 Rodgers et al.
• First Published: First published in PLoS Neglected Tropical Diseases 9(10)e0004201
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
45790	1	Defining the therapeutic role of IL-10 in African trypanosomiasis.	Peter Kennedy	Wellcome Trust (WELLCOME)	082786/Z/07/Z	III - PARASITOLOGY
55490	1	Defining the role of kynurenine pathway metabolites in the inflammatory response to trypanosome invasion of the CNS	Peter Kennedy	Wellcome Trust (WELLCOME)	094691/Z/10/Z	III - PARASITOLOGY