Pontrelli, G. and McGinty, S. (2014) Drug Delivery in Biological Tissues: A Two-Layer Reaction-Diffusion-Convection Model. In: 18th European Conference on Mathematics for Industry 2014, Taormina, Italy, 9-13 June 2014,
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111652.pdf - Accepted Version 107kB |
Abstract
In this paper we present a general model of drug release from a drug delivery device and the subsequent drug transport in biological tissue. In order to study the complete process, a two-phase mathematical model describing the transport of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid-liquid transfer and diffusion processes in the polymeric substrate as well as diffusion, convection and reaction in the tissue layer. The model serves as a useful tool for providing insight into the concurrent effects of the diffusion, convection, solid-liquid transfer and reaction parameters in drug delivery systems.
Item Type: | Conference Proceedings |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mcginty, Dr Sean |
Authors: | Pontrelli, G., and McGinty, S. |
College/School: | College of Science and Engineering |
Copyright Holders: | Copyright © 2014 The Authors |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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