Drug Delivery in Biological Tissues: A Two-Layer Reaction-Diffusion-Convection Model

Pontrelli, G. and McGinty, S. (2014) Drug Delivery in Biological Tissues: A Two-Layer Reaction-Diffusion-Convection Model. In: 18th European Conference on Mathematics for Industry 2014, Taormina, Italy, 9-13 June 2014,

111652.pdf - Accepted Version



In this paper we present a general model of drug release from a drug delivery device and the subsequent drug transport in biological tissue. In order to study the complete process, a two-phase mathematical model describing the transport of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid-liquid transfer and diffusion processes in the polymeric substrate as well as diffusion, convection and reaction in the tissue layer. The model serves as a useful tool for providing insight into the concurrent effects of the diffusion, convection, solid-liquid transfer and reaction parameters in drug delivery systems.

Item Type:Conference Proceedings
Glasgow Author(s) Enlighten ID:Mcginty, Dr Sean
Authors: Pontrelli, G., and McGinty, S.
College/School:College of Science and Engineering
Copyright Holders:Copyright © 2014 The Authors
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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