Actin regulation in endocytosis

Ayscough, K. and Smythe, D. (2006) Actin regulation in endocytosis. Journal of Cell Science, 119(22), pp. 4589-4598. (doi:10.1242/jcs.03247)

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Abstract

Increasing evidence from a variety of cell types has highlighted the importance of the actin cytoskeleton during endocytosis. No longer is actin viewed as a passive barrier that must be removed to allow endocytosis to proceed. Rather, actin structures are dynamically organised to assist the remodelling of the cell surface to allow inward movement of vesicles. The majority of our mechanistic insight into the role of actin in endocytosis has come from studies in budding yeast. Although endocytosis in mammalian cells is clearly more complex and subject to a greater array of regulatory signals, recent advances have revealed actin, and actin-regulatory proteins, to be present at endocytic sites. Furthermore, live cell imaging indicates that spatiotemporal aspects of actin recruitment and vesicle formation are likely to be conserved across eukaryotic evolution.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smythe, Professor David
Authors: Ayscough, K., and Smythe, D.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Journal of Cell Science
ISSN:1477-9137
ISSN (Online):0021-9533

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
296121The regulation and coupling of endocytosis to dynamic changes in the actin cytoskeletonKathryn AyscoughMedical Research Council (MRC)G117/394Biochemistry & Cell Biology