On the influence of solid–liquid mass transfer in the modelling of drug release from stents

Mcginty, S. and Pontrelli, G. (2015) On the influence of solid–liquid mass transfer in the modelling of drug release from stents. Journal of Coupled Systems and Multiscale Dynamics, 3(1), pp. 47-56. (doi:10.1166/jcsmd.2015.1064)

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Abstract

In this paper we present a model of drug release from a drug eluting-stent and the subsequent drug transport in the arterial wall. In order to study the complete process, a two-phase mathematical model describing the transport of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid–liquid transfer (dissolution) and diffusion processes in the polymeric substrate as well as diffusion, convection and reaction in the tissue layer. We adopt a semi-analytical approach in solving the four resulting equations. The model serves as a useful tool for providing insight into the influence of solid–liquid mass transfer in drug-eluting stent systems.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mcginty, Dr Sean
Authors: Mcginty, S., and Pontrelli, G.
College/School:College of Science and Engineering > School of Engineering
Journal Name:Journal of Coupled Systems and Multiscale Dynamics
Publisher:American Scientific Publishers
ISSN:2330-152X
ISSN (Online):2330-1538

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