Interactions between the constitutive host defences of tears and Staphylococcus epidermidis

Leitch, E.C. and Willcox, M.D.P. (1997) Interactions between the constitutive host defences of tears and Staphylococcus epidermidis. Australian and New Zealand Journal of Ophthalmology, 25(4), pp. 20-22. (doi:10.1111/j.1442-9071.1997.tb01747.x) (PMID:9267616)

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Abstract

As part of the normal microbiota of the external eye, Staphylococcus epidermidis has probably developed strategies to overcome tear defences. The interaction of this bacteria with constitutive tear proteins was examined. Isolates of S. epidermidis grown in 10% serum or artificial tear fluid containing lysozyme or lactoferrin were resistant to the action of these proteins. Using ELISA, cell wall binding of C3, vitronectin and lactoferrin differed quantitatively between strains and in closed-eye compared to open-eye conditions. No differences were observed between ocular and non-ocular strains. This suggests that ocular isolates originate from the general host microbiota and S. epidermidis isolates are resistant to individual constitutive tear proteins.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Leitch, Dr Carol
Authors: Leitch, E.C., and Willcox, M.D.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Australian and New Zealand Journal of Ophthalmology
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0814-9763
ISSN (Online):1440-1606

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