Research into cancer metabolomics: towards a clinical metamorphosis

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E. and Halsey, C. (2015) Research into cancer metabolomics: towards a clinical metamorphosis. Seminars in Cell and Developmental Biology, 43, pp. 52-64. (doi: 10.1016/j.semcdb.2015.09.008) (PMID:26365277)

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Abstract

The acknowledgement that metabolic reprogramming is a central feature of cancer has generated high expectations for major advances in both diagnosis and treatment of malignancies through addressing metabolism. These have so far only been partially fulfilled, with only a few clinical applications. However, numerous diagnostic and therapeutic compounds are currently being evaluated in either clinical trials or pre-clinical models and new discoveries of alterations in metabolic genes indicate future prognostic or other applicable relevance. Altogether, these metabolic approaches now stand alongside other available measures providing hopes for the prospects of metabolomics in the clinic. Here we present a comprehensive overview of both ongoing and emerging clinical, pre-clinical and technical strategies for exploiting unique tumour metabolic traits, highlighting the current promises and anticipations of research in the field.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:King, Dr Ayala and Däbritz, Jan and Olivares, Miss Orianne and Halsey, Professor Chris and Gottlieb, Professor Eyal
Authors: Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E., and Halsey, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Seminars in Cell and Developmental Biology
Publisher:Elsevier
ISSN:1084-9521
ISSN (Online):1096-3634
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Seminars in Cell and Developmental Biology 43:52-64
Publisher Policy:Reproduced under a Creative Commons licence

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