Racys, D. T., Warrilow, C. E., Pimlott, S. L. and Sutherland, A. (2015) Highly regioselective iodination of arenes via iron(III)-catalyzed activation of N-iodosuccinimide. Organic Letters, 17(19), pp. 4782-4785. (doi: 10.1021/acs.orglett.5b02345) (PMID:26394175)
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Abstract
An iron(III)-catalyzed method for the rapid and highly regioselective iodination of arenes has been developed. Use of the powerful Lewis acid, iron(III) triflimide, generated in situ from iron(III) chloride and a readily available triflimide-based ionic liquid allowed activation of N-iodosuccinimide (NIS) and efficient iodination under mild conditions of a wide range of substrates including biologically active compounds and molecular imaging agents.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Pimlott, Dr Sally and Sutherland, Professor Andrew and Racys, Dr Daugirdas |
| Authors: | Racys, D. T., Warrilow, C. E., Pimlott, S. L., and Sutherland, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering > School of Chemistry |
| Journal Name: | Organic Letters |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7060 |
| ISSN (Online): | 1523-7052 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Organic Letters 17(19):4782-4785 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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