Mechanical and Degradation Characterization of AZ31 Magnesium (Mg) for use in Paediatric Tracheal Stents

Adekanmbi, I. , Tanner, K., Kubba, H. and Lu, H. (2015) Mechanical and Degradation Characterization of AZ31 Magnesium (Mg) for use in Paediatric Tracheal Stents. In: 27th European Conference of Biomaterials, Krakow, Poland, 30 Aug-3 Sep 2015, ISBN 9788363663629

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The trachea (windpipe) consists of rigid cartilage rings in a soft tissue network. In infant airways, deficiency of these supportive structures (Tracheomalacia) may occur at 1.3 affected per million children below the age of 16, predisposing airway constriction (tracheal stenosis)1 and leading to significant problems with breathing. Current treatment options involve reconstructive surgery. However when this fails a cardiovascular balloon expandable stent is used in the trachea2. The stent is required to provide mechanical support for a minimum of 18 months to allow maturation of the dysfunctional tracheal cartilage3. Issues arise however with commercially available permanent metallic airway stent materials (Nitinol or stainless steel) which require multiple surgical procedures for surveillance, removal, resectioning and possible reconstruction of the airways. Mg alloys have received attention for use as medical implants, but until now have not clinically approved for use in airway stents. In this study the degradation behaviour and associated changes in mechanical properties with in vitro degradation of AZ31 Mg alloys was used to test the hypothesis that a biodegradable metallic tracheal expansion stent with appropriate mechanical and degradation characteristics can be developed for use in neonates.

Item Type:Conference Proceedings
Glasgow Author(s) Enlighten ID:Adekanmbi, Dr Isaiah and Kubba, Mr Haytham
Authors: Adekanmbi, I., Tanner, K., Kubba, H., and Lu, H.
Subjects:R Medicine > RF Otorhinolaryngology
R Medicine > RJ Pediatrics
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
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