Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum

Mistry, H.D., Eisele, N., Escher, G., Dick, B., Surbek, D., Delles, C. , Currie, G. , Schlembach, D., Mohaupt, M.G. and Gennari-Moser, C. (2015) Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum. Reproductive Biology and Endocrinology, 13, 101. (doi: 10.1186/s12958-015-0100-6) (PMID:26337185) (PMCID:PMC4559160)

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Abstract

Background: Normal pregnancy depends on pronounced adaptations in steroid hormone concentrations. Although in recent years, the understanding of these hormones in pregnancy has improved, the interpretation is hampered by insufficient reference values. Our aim was to establish gestation-specific reference intervals for spot urinary steroid hormone levels in normal singleton pregnancies and 6 weeks postpartum. Methods: Cross-sectional multicentre observational study. Women recruited between 2008 and 2013 at 3 University Hospitals in Switzerland (Bern), Scotland (Glasgow) and Austria (Graz). Spot urine was collected from healthy women undergoing a normal pregnancy (age, 16–45 years; mean, 31 years) attending routine antenatal clinics at gestation weeks 11, 20, and 28 and approximately 6 weeks postpartum. Urine steroid hormone levels were analysed using gas-chromatography mass spectrometry. Creatinine was also measured by routine analysis and used for normalisation. Results: From the results, a reference interval was calculated for each hormone metabolite at each trimester and 6 weeks postpartum. Changes in these concentrations between trimesters and postpartum were also observed for several steroid hormones and followed changes proposed for index steroid hormones. Conclusions: Normal gestation-specific reference values for spot urinary steroid hormones throughout pregnancy and early postpartum are now available to facilitate clinical management and research approaches to steroid hormone metabolism in pregnancy and the early postpartum period.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Currie, Dr Gemma and Delles, Professor Christian
Authors: Mistry, H.D., Eisele, N., Escher, G., Dick, B., Surbek, D., Delles, C., Currie, G., Schlembach, D., Mohaupt, M.G., and Gennari-Moser, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Reproductive Biology and Endocrinology
Publisher:Biomed Central
ISSN:1477-7827
ISSN (Online):1477-7827
Copyright Holders:Copyright © 2015 Mistry et al.
First Published:First published in Reproductive Biology and Endocrinology 13:101
Publisher Policy:Reproduced under a Creative Commons License

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