Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei

McCulloch, R. and Field, M. C. (2015) Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei. Trends in Parasitology, 31(8), pp. 346-349. (doi:10.1016/j.pt.2015.05.001) (PMID:25999027)

Full text not currently available from Enlighten.

Abstract

Antigenic variation is central to the virulence of African trypanosomes, where the VSG coat is used to evade the host immune system. Recent advances in technology have now allowed more secrets of this system to emerge, with the surprising insight that a broad repertoire of VSGs is rapidly expressed. This has major implications for how the parasite must evade the host immune response.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McCulloch, Professor Richard
Authors: McCulloch, R., and Field, M. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Parasitology
Publisher:Elsevier Ltd.
ISSN:1471-4922
ISSN (Online):1471-5007

University Staff: Request a correction | Enlighten Editors: Update this record