Castro-Perez, J. M., Kamphorst, J. , DeGroot, J., Lafeber, F., Goshawk, J., Yu, K., Shockcor, J. P., Vreeken, R. J. and Hankemeier, T. (2010) Comprehensive LC−MSELipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients. Journal of Proteome Research, 9(5), pp. 2377-2389. (doi: 10.1021/pr901094j) (PMID:20355720)
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Abstract
A “shotgun lipidomic LC−MS approach” was developed by the use of high resolution and exact mass. A total of 284 lipids were identified in human plasma. The method was validated with five nonendogenous lipids, the linearity (r2 > 0.994) and the intraday and interday repeatability (RSD, 4.3−6.2% and 4.8−8%, respectively) were satisfactory. The developed lipid profiling method was applied for the analysis of plasma from humans suffering from osteoarthritis (OA).
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kamphorst, Dr Jurre |
| Authors: | Castro-Perez, J. M., Kamphorst, J., DeGroot, J., Lafeber, F., Goshawk, J., Yu, K., Shockcor, J. P., Vreeken, R. J., and Hankemeier, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Journal of Proteome Research |
| Publisher: | American Chemical Society |
| ISSN: | 1535-3893 |
| ISSN (Online): | 1535-3907 |
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