New metrics needed to visualize the long-term impact of early LDL-C lowering on the cardiovascular disease trajectory

Packard, C. J. , Weintraub, W. S. and Laufs, U. (2015) New metrics needed to visualize the long-term impact of early LDL-C lowering on the cardiovascular disease trajectory. Vascular Pharmacology, 71, pp. 37-39. (doi: 10.1016/j.vph.2015.03.008) (PMID:25889746)

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Abstract

Short-term absolute cardiovascular event rates in young/middle-aged people are low even if they have risk factors, and parameters such as number-needed-to-treat over 5 years are inadequate to visualize and to communicate the lifelong benefit of interventions such as statin therapy to individuals and to healthcare providers. To understand more fully the impact of risk factors, and lifestyle and pharmacological interventions, there is a need to focus on disease trajectory over a lifetime and to develop new metrics of success. A shift to primordial (‘true’) prevention of the formation of atherosclerotic lesions will require new tools and approaches in the interaction between physicians and patients as individuals or populations.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Packard, Professor Chris
Authors: Packard, C. J., Weintraub, W. S., and Laufs, U.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Vascular Pharmacology
Publisher:Elsevier Inc.
ISSN:1537-1891
ISSN (Online):1879-3649

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