BIM's up first

Murphy, D. J. and Muthalagu, N. (2015) BIM's up first. Molecular and Cellular Oncology, 2(2), e975083. (doi: 10.4161/23723556.2014.975083)

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Abstract

In vivo analysis of the genetic determinants of Myc-induced apoptosis reveals a specific requirement for the Bcl2 family protein Bim (Bcl2l11). Surprisingly, apoptosis induced by Myc in multiple solid tissues does not require p19Arf (Cdkn2a), whereas Puma (Bbc3) is required only in the context of sensitization by Myc to death induced by DNA damage.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Murphy, Professor Daniel
Authors: Murphy, D. J., and Muthalagu, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Molecular and Cellular Oncology
Publisher:Taylor and Francis
ISSN:2372-3548
ISSN (Online):2372-3556
Published Online:01 December 2014
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Molecular & Cellular Oncology 2(2):e975083
Publisher Policy:Reproduced under a Creative Commons License

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