Mechanisms of apical–basal axis orientation and epithelial lumen positioning

Overeem, A. W., Bryant, D. M. and van IJzendoorn, S. C.D. (2015) Mechanisms of apical–basal axis orientation and epithelial lumen positioning. Trends in Cell Biology, 25(8), pp. 476-485. (doi:10.1016/j.tcb.2015.04.002) (PMID:25941134)

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Abstract

In epithelial cells, the polarized orientation of the apical–basal axis determines the position of the apical lumen and, thereby, the collective tubular tissue architecture. From recent studies employing 3D cell cultures, animal models, and patient material, a model is emerging in which the orientation and positioning of the apical surface and lumen is controlled by the relationships between the extracellular matrix (ECM), Rho family GTPase signaling, recycling endosome dynamics, and cell division. Different epithelial cells adjust these relationships to establish their specific cell polarity orientation and lumen positioning, according to physiologic need. We provide an overview of the molecular mechanisms required to construct and orient the apical lumen.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bryant, Dr David
Authors: Overeem, A. W., Bryant, D. M., and van IJzendoorn, S. C.D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Trends in Cell Biology
Publisher:Elsevier Ltd.
ISSN:0962-8924
ISSN (Online):1879-3088
Published Online:01 May 2015

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