Current and future prophylactic vaccines for hepatitis C virus

Dunlop, J., Owsianka, A., Cowton, V. and Patel, A. (2015) Current and future prophylactic vaccines for hepatitis C virus. Vaccine: Development and Therapy, 2015(5), pp. 31-44. (doi:10.2147/VDT.S48437)

[img]
Preview
Text
109438.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

1MB

Abstract

The development of a vaccine is necessary to combat the global hepatitis C virus (HCV) epidemic. The key to the development of a prophylactic vaccine is understanding the immune response in those who spontaneously resolve HCV infections versus those who develop chronic disease. Several promising vaccine candidates based on the use of viral vectors are currently in Phase I and Phase II clinical trials. The recently solved structures of the E2 glycoprotein have greatly aided epitope- and antibody-based vaccine design.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cowton, Dr Vanessa and Dunlop, Dr James and Owsianka, Dr Anna and Patel, Professor Arvind
Authors: Dunlop, J., Owsianka, A., Cowton, V., and Patel, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Vaccine: Development and Therapy
Publisher:Dove Medical Press
ISSN:2230-2298
ISSN (Online):2230-2298
Copyright Holders:Copyright © 2015 Dunlop et al.
First Published:First published in Vaccine: Development and Therapy 2015(5):31-44
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656491Basis of the host range and tissue tropism for hepatitis C virusArvind PatelMedical Research Council (MRC)MC_UU_12014/2MVLS III - CENTRE FOR VIRUS RESEARCH