Dunlop, J., Owsianka, A., Cowton, V. and Patel, A. (2015) Current and future prophylactic vaccines for hepatitis C virus. Vaccine: Development and Therapy, 2015(5), pp. 31-44. (doi: 10.2147/VDT.S48437)
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Abstract
The development of a vaccine is necessary to combat the global hepatitis C virus (HCV) epidemic. The key to the development of a prophylactic vaccine is understanding the immune response in those who spontaneously resolve HCV infections versus those who develop chronic disease. Several promising vaccine candidates based on the use of viral vectors are currently in Phase I and Phase II clinical trials. The recently solved structures of the E2 glycoprotein have greatly aided epitope- and antibody-based vaccine design.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cowton, Dr Vanessa and Dunlop, Dr James and Owsianka, Dr Anna and Patel, Professor Arvind |
| Authors: | Dunlop, J., Owsianka, A., Cowton, V., and Patel, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Vaccine: Development and Therapy |
| Publisher: | Dove Medical Press |
| ISSN: | 2230-2298 |
| ISSN (Online): | 2230-2298 |
| Copyright Holders: | Copyright © 2015 Dunlop et al. |
| First Published: | First published in Vaccine: Development and Therapy 2015(5):31-44 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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