Patient-centric trials for therapeutic development in precision oncology

Biankin, A. V. , Piantadosi, S. and Hollingsworth, S. J. (2015) Patient-centric trials for therapeutic development in precision oncology. Nature, 526, pp. 361-370. (doi:10.1038/nature15819) (PMID:26469047)




An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours. Considerable associated challenges include how to advance and implement targeted drug-development strategies. Precision medicine centres on delivering the most appropriate therapy to a patient on the basis of clinical and molecular features of their disease. The development of therapeutic agents that target molecular mechanisms is driving innovation in clinical-trial strategies. Although progress has been made, modifications to existing core paradigms in oncology drug development will be required to realize fully the promise of precision medicine.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Biankin, Professor Andrew
Authors: Biankin, A. V., Piantadosi, S., and Hollingsworth, S. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Nature
Publisher:Nature Publishing Group
ISSN (Online):1476-4687
Copyright Holders:Copyright © 2015 The London School of Economics and Political Science
First Published:First published in Nature 526:361-370
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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