Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes

Kean, J., Rainey, S., McFarlane, M. , Donald, C. , Schnettler, E., Kohl, A. and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi:10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

Kean, J., Rainey, S., McFarlane, M. , Donald, C. , Schnettler, E., Kohl, A. and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi:10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

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Abstract

Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of biological approaches, both natural or engineered, to limit mosquito vector competence for arboviruses. The study of mosquito antiviral immunity has led to the identification of a number of host response mechanisms and proteins that are required to control arbovirus replication in mosquitoes, though more factors influencing vector competence are likely to be discovered. We will discuss key aspects of these pathways as targets either for selection of naturally resistant mosquito populations or for mosquito genetic manipulation. Moreover, we will consider the use of endosymbiotic bacteria such as Wolbachia, which in some cases have proven to be remarkably efficient in disrupting arbovirus transmission by mosquitoes, but also the use of naturally occurring insect-specific viruses that may interfere with arboviruses in mosquito vectors. Finally, we will discuss the use of paratransgenesis as well as entomopathogenic fungi, which are also proposed strategies to control vector competence.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Schnettler, Dr Esther and Kean, Dr Joy and Rainey, Dr Stephanie and Pondeville, Dr Emilie and Mcdonald, Dr Melanie and Donald, Dr Claire and Kohl, Professor Alain
Authors: Kean, J., Rainey, S., McFarlane, M., Donald, C., Schnettler, E., Kohl, A., and Pondeville, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Insects
Publisher:M D P I AG
ISSN:2075-4450
ISSN (Online):2075-4450
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Insects 6(1):236-278
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
643541Wolbachia as a defence against RNA viruses in insectsAlain KohlWellcome Trust (WELLCOME)094664/Z/10/ZMVLS III - CENTRE FOR VIRUS RESEARCH