Contextual feedback to superficial layers of V1

Muckli, L. , De Martino, F., Vizioli, L., Petro, L. S. , Smith, F. W., Ugurbil, K., Goebel, R. and Yacoub, E. (2015) Contextual feedback to superficial layers of V1. Current Biology, 25(20), pp. 2690-2695. (doi:10.1016/j.cub.2015.08.057) (PMID:26441356) (PMCID:PMC4612466)

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Abstract

Neuronal cortical circuitry comprises feedforward, lateral, and feedback projections, each of which terminates in distinct cortical layers [ 1–3 ]. In sensory systems, feedforward processing transmits signals from the external world into the cortex, whereas feedback pathways signal the brain’s inference of the world [ 4–11 ]. However, the integration of feedforward, lateral, and feedback inputs within each cortical area impedes the investigation of feedback, and to date, no technique has isolated the feedback of visual scene information in distinct layers of healthy human cortex. We masked feedforward input to a region of V1 cortex and studied the remaining internal processing. Using high-resolution functional brain imaging (0.8 mm3) and multivoxel pattern information techniques, we demonstrate that during normal visual stimulation scene information peaks in mid-layers. Conversely, we found that contextual feedback information peaks in outer, superficial layers. Further, we found that shifting the position of the visual scene surrounding the mask parametrically modulates feedback in superficial layers of V1. Our results reveal the layered cortical organization of external versus internal visual processing streams during perception in healthy human subjects. We provide empirical support for theoretical feedback models such as predictive coding [ 10, 12 ] and coherent infomax [ 13 ] and reveal the potential of high-resolution fMRI to access internal processing in sub-millimeter human cortex.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Petro, Dr Lucy and Muckli, Professor Lars and Vizioli, Dr Luca and Smith, Dr Fraser
Authors: Muckli, L., De Martino, F., Vizioli, L., Petro, L. S., Smith, F. W., Ugurbil, K., Goebel, R., and Yacoub, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Current Biology
Publisher:Elsevier Inc.
ISSN:0960-9822
ISSN (Online):1879-0445
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Current Biology 2015
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
593891Brain reading of contextual feedback and predictions - BrainReadFBPredCodeLars MuckliEuropean Research Council (ERC)ERC-2012-Stg-31INP - CENTRE FOR COGNITIVE NEUROIMAGING