An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15

Bachelerie, F., Graham, G.J. , Locati, M., Mantovani, A., Murphy, P.M., Nibbs, R. , Rot, A., Sozzani, S. and Thelen, M. (2015) An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15. British Journal of Pharmacology, 172(16), pp. 3945-3949. (doi:10.1111/bph.13182) (PMID:25958743)

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Abstract

Chemokines and their receptors are essential regulators of in vivo leukocyte migration and, some years ago, a systematic nomenclature system was developed for the chemokine receptor family. Chemokine receptor biology and biochemistry was recently extensively reviewed. In this review, we also highlighted a new component to the nomenclature system that incorporates receptors previously known as ‘scavenging’, or ‘decoy’, chemokine receptors on the basis of their lack of classical signalling responses to ligand binding and their general ability to scavenge, or sequester, their cognate chemokine ligands. These molecules are now collectively referred to as ‘atypical chemokine receptors’, or ACKRs, and play fundamental roles in regulating in vivo responses to chemokines. This commentary highlights this new addition to the chemokine receptor nomenclature system and provides brief information on the four receptors currently covered by this nomenclature.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nibbs, Professor Robert and Graham, Professor Gerard
Authors: Bachelerie, F., Graham, G.J., Locati, M., Mantovani, A., Murphy, P.M., Nibbs, R., Rot, A., Sozzani, S., and Thelen, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:British Journal of Pharmacology
Publisher:John Wiley & Sons, Inc.
ISSN:0007-1188
ISSN (Online):1476-5381

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