Identifying in vivo pathways using genome-wide genetic networks

Gray, J.V. and Krause, S.A. (2007) Identifying in vivo pathways using genome-wide genetic networks. Biochemical Society Transactions, 35(Pt6), pp. 1538-1541. (doi: 10.1042/BST0351538) (PMID:18031262)

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Synthetic genetic interactions occur between two genes when the double mutant displays a phenotype much more severe than does either single mutant alone. Global networks of such interactions are now being systematically determined, spearheaded by the budding yeast genome. Genetic interactions reflect in vivo relationships between gene products. Extracting that functional information from such genetic networks is now possible by exploiting and modifying the key concept of congruence. Here, we focus on synthetic genetic interactions between pairs of null mutations in non-essential yeast genes. We summarize how to identify biological pathways from these emerging networks, using illustrative examples.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Gray, Professor Joseph and Krause, Dr Sue
Authors: Gray, J.V., and Krause, S.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Biochemical Society Transactions
Publisher:Portland Press
ISSN (Online):1470-8752
Published Online:01 January 2007

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