Applying refinement to the use of mice and rats in rheumatoid arthritis research

Hawkins, P., Armstrong, R., Boden, T., Garside, P. , Knight, K., Lilley, E., Seed, M., Wilkinson, M. and Williams, R. O. (2015) Applying refinement to the use of mice and rats in rheumatoid arthritis research. Inflammopharmacology, 23(4), pp. 131-150. (doi:10.1007/s10787-015-0241-4) (PMID:26168847) (PMCID:PMC4508365)

Hawkins, P., Armstrong, R., Boden, T., Garside, P. , Knight, K., Lilley, E., Seed, M., Wilkinson, M. and Williams, R. O. (2015) Applying refinement to the use of mice and rats in rheumatoid arthritis research. Inflammopharmacology, 23(4), pp. 131-150. (doi:10.1007/s10787-015-0241-4) (PMID:26168847) (PMCID:PMC4508365)

[img]
Preview
Text
108706.pdf - Published Version
Available under License Creative Commons Attribution.

1MB

Abstract

Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo studies, which have the potential to cause discomfort, pain or distress. This Working Group report focuses on identifying causes of suffering within commonly used mouse and rat ‘models’ of RA, describing practical refinements to help reduce suffering and improve welfare without compromising the scientific objectives. The report also discusses other, relevant topics including identifying and minimising sources of variation within in vivo RA studies, the potential to provide pain relief including analgesia, welfare assessment, humane endpoints, reporting standards and the potential to replace animals in RA research.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Garside, Professor Paul and Wilkinson, Dr Michael
Authors: Hawkins, P., Armstrong, R., Boden, T., Garside, P., Knight, K., Lilley, E., Seed, M., Wilkinson, M., and Williams, R. O.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Inflammopharmacology
Publisher:Springer Basel
ISSN:0925-4692
ISSN (Online):1568-5608
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Inflammopharmacology 23(4):131-150
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record